A QFG-style hybrid would be great. Doesn't have to be fantasy though, I'd be happy with a sci-fi or a mystery as well. (Gotta agree with coroloro on Al Emmo though, it was a good game but I'm just not a big fan of the genre.)
On the interface: I'm not a big fan of everything having a description. It's nice, but I'm ultimately only going to see a small portion of the text that's written for background objects. Of the adventures I've played - haven't played many recent ones though - Grim Fandango's hotspot system is probably one of my favorites. (Thing is, GF's worked well because it was entirely keyboard, so you actually had to move around to investigate rather than just mouse over stuff. Not sure it would work that well for point-and-click.)
On the interface: I'm not a big fan of everything having a description. It's nice, but I'm ultimately only going to see a small portion of the text that's written for background objects. Of the adventures I've played - haven't played many recent ones though - Grim Fandango's hotspot system is probably one of my favorites. (Thing is, GF's worked well because it was entirely keyboard, so you actually had to move around to investigate rather than just mouse over stuff. Not sure it would work that well for point-and-click.)